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The crux of this argument is that the typical experimental artificial cerebrospinal fluid (aCSF) used in in vitro experiments is based on adult brain CSF, which may not mimic the CSF of the young mouse brain well.
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While a perturbation of the glutamate-glutamine cycle in the Mecp2-null mouse brain is well supported by our data, mechanistic details remain to be elucidated.
The split-Cre systems allows for a more precise 'genetic access' [47] of (sub-) populations of cells, which will offer advanced analysis of gene and cell function in the mouse brain, as well as in other organs.
Pax3 is regionally expressed in the neonatal mouse brain as well, characterizing a subset of Nestin progenitors in the brainstem but not in the cerebral cortex.
The capability of FMM is demonstrated by imaging fluorescence labeled vasculatures in mouse brain as well as self-made tissue phantom.
We have validated the capability of FMM in improving image quality at large penetration depth by visualizing blood vessels in whole mouse brain as well as tissue phantom.
SDS-stable TDP-43 homodimers were observed in various human cell lines and in mouse brain, as well as in vitro using recombinant TDP-43.
Together, our data provide new insight into the p53 transcriptional network in the developing mouse brain as well as in some of the transcriptional changes that occur during the earliest stages of mouse brain development.
The highest expression of NRSF is observed in the mouse embryonic cortex at E14, but is also detected in the adult mouse brain as well as in cultured cortical neurons (Qiang et al. 2005).
No direct interaction of huntingtin and parkin has been described to date although studies confirmed the colocalization of parkin and huntingtin in mouse brain as well as in patient samples [ 168].
TDP-43 is the principal pathogenic protein in tau-negative fronto-temporal dementia (FTLD-TDP) and in many forms of ALS, and at the transcript level is very highly circadian in mouse brain, as well as in liver and kidney.
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