Accordingly, RNA-seq data from the adult mouse brain supported the use of only the upstream promoter in this tissue.
Our work documents the presence of homotopic cortical and subcortical scMRI networks in the mouse brain, thus supporting the use of this species to investigate the elusive biological and neuroanatomical underpinnings of scMRI network development and its derangement in neuropathological states.
Immunogold electron microscopic analysis of mouse brain further supports AIF association with the outer, as well as the inner, mitochondrial membrane in vivo.
While a perturbation of the glutamate-glutamine cycle in the Mecp2-null mouse brain is well supported by our data, mechanistic details remain to be elucidated.
Cervidized Prnp transgenic mouse brain homogenate can support CWD prion replication (32 ), and extensive in vitro conditioning of a CWD isolate by PMCA in a cervidized substrate (or passage in cervidized mice) was sufficient to overcome the barrier and enable efficient in vitro amplification in a humanized transgenic mouse substrate (33 ).
Native GluA4 and SAP97 coimmunoprecipitated from mouse brain independently of the GluA1 subunit, supporting the possibility of in vivo PDZ interaction.
In particular, we have previously reported that the expression of microRNAs (miRNAs) may be globally altered in the adult mouse brain following PAE [ 6], which supports recent data by other groups [ 7, 8].
In agreement with this, MeCP2-null mouse brain shows a twofold increase in H1, supporting the idea that, in the brain, MeCP2 binds half of the nucleosomes and H1 binds the other half (Skene et al., 2010).
The glycoslyation motif in WNV may be lost during extensive mouse brain passage; however, no direct evidence exists to support this hypothesis (21 ).
No teratoma formation was observed in any mouse brains examined, which further supports the safety of ipNPCs in vivo.
