Sentence examples for mouse brain model from inspiring English sources

These results were confirmed in the mouse brain model, suggesting that DAPK1 KO decreased tau phosphorylation at AD-related sites.

Thus, our results indicate that DAPK1 KO dramatically decreased tau phosphorylation in whole-brain lysates and inhibited tau-related pathological phenotypes such as NFT conformations in sarkosyl-insoluble fraction in an age-dependent manner in the mouse brain model.

Whether linagliptin could offer benefits following stroke is another possible area for further research in light of preclinical findings that have demonstrated a glucose-independent neuroprotective effect of linagliptin in the diabetic mouse brain model, possibly as a result of neural stem cell proliferation [ 34].

HD cell culture models and HD mouse brain models show alterations in Bcl-2 family protein expression and localization.

We found that the DAPK1 significantly enhanced tau protein expression and stability in cell culture and mouse brain models.

Presence of EREG and HB-EGF mRNAs in U87 cells was also monitored in human tumor xenografts using the chicken chorio-allantoic membrane (CAM) and the mouse brain models.

To more accurately reflect the situation in normal brain, the binding of these peptides to adult neurons was also determined in a mouse brain slice model.

In addition, recent IVM and MRI studies in a U87 mouse brain tumor model demonstrated that cediranib significantly prolongs survival despite persistent tumor growth, where the survival benefit was primarily attributed to decreased vascular permeability and reduction of edema [20].

The fact that the VCI and ADC were not sensitive to cediranib therapy in our mouse brain tumor model, in contrast to the clinical cediranib study [7], suggests that the sensitivity of a particular MRI biomarker varies depending on which physiological factors are being altered most by a given therapy for a particular tumor.

While the clinical study did observe a transient decrease in rVCI that was not observed in our mouse brain tumor model, this might simply reflect somewhat different relative responses of the rMBV and rCBV in the clinical subjects, where a greater decrease is observed for the rCBV than rMBV.

This series was chosen because of relation to aging in the mouse brain, mouse model type, state number and sample size.