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Acquisition of light microscopic data at 1-micrometer resolution for an entire mouse brain has been developed.
Pten deletion in the mouse brain has revealed its role in controlling cell size and number.
The distribution of MORs in the mouse brain has previously been investigated using immunohistochemistry and molecular biology [46].
Recent phenotypic characterization of Sez-6 null-mutant mouse brain has revealed a role for Sez-6 in specifying dendritic branching patterns of cortical neurons [4].
Second, we have shown that aged female mouse brain has 65% more in vitro γ-secretase activity at 24 months compared to male mice.
Moreover, preferential expression of TIP60 in the mouse brain has been reported [18] and a recent study reported Bap55 as a chromatin remodeling factor that functions through the TIP60 complex to regulate olfactory projection neuron dendrite targeting in Drosophila [70].
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Comprehensive studies on miRNA expression throughout the mouse brain have been published [39], [40], but comparable studies in rats are lacking.
However, there are clear species and/or tissue differences with respect to the effects of PINK1, as experiments in mouse brain have not revealed any obvious changes in mitochondrial morphology in the absence of exogenous stressors [18].
Two studies in the healthy adult mouse brain have revealed significant regional variations in the distribution of these molecules.
Neuronal connections in the mouse brain have been investigated more thoroughly than in virtually any other mammalian species.
It has not been previously reported that gliomas induced with the same genetic alterations in different regions of the mouse brain have distinct gene expression.
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