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After intraventricular injection, brain MR imaging was performed at 7.0T micro-MR scanner (PharmaScan, Bruker, Germany) with a 23 mm mouse brain coil.
Subsequently, animals were placed in a 1 T Icon-Scanner (Bruker, Ettlingen, Germany) equipped with a mouse brain coil and T2-weighted images of the brain were acquired.
MRI data were collected on anaesthetized, monitored mice using an Agilent 7T preclinical scanner (Agilent Technologies), with a 72 mm volume coil and a phased array mouse brain coil (Rapid Biomedical).
The imaging was performed using a Bruker Biospin 94/30 magnet (Bruker Biospin, MA), a 2.0 cm diameter receive-only mouse brain coil, and a 70 mm diameter linear volume coil.
A four-channel receive-array mouse brain coil and a transmit volume coil were used to run a two-dimensional T2-weighted TURBO-RARE protocol with the following parameters: TR, 4660 ms; TE, 36 ms; Matrix, 256 × 256; FOV, 3.5 × 3.5 cm; Slice thickness, 0.5 mm; and Averages, 4. Bruker Paravision 5.1 software was used to calculate tumor volumes.
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Samples were introduced into a H mouse brain radio frequency (RF) coil (inner diameter 22 mm), and centered in the magnet.
In particular, for mouse brain images obtained with a surface RF coil, no arteries are typically visible from which to measure an AIF.
A 30 mm birdcage coil was used which surrounds the mouse brain.
We present the design process of a superconducting volume coil for magnetic resonance microscopy of the mouse brain at 9.4 T.
An 11.7 T 89 mm vertical bore Bruker BioSpin Avance DRX500 scanner (Bruker BioSpin Inc, Billerica, MA) equipped with a Micro2.5 gradient system was used to acquire all mouse brain images and spectroscopic data with a 35 mm linear birdcage radio frequency (RF) coil.
Signal-to-noise ratio in a mouse brain increased by a factor ranging from 1.1 to 2.9 as compared to a room-temperature solenoid coil optimized for mouse brain microscopy.
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