Sentence examples for mouse biliary epithelial from inspiring English sources
l4 – C. Wang and J. Xu, MG-U74Av2, mouse biliary epithelial cells.
By liver-specific disruption of PTEN and activation of Kras in mice caused rapid development of intrahepatic biliary epithelial proliferative lesions (Intrahepatic cholangiocarcinoma, ICC), which progress through dysplasia to invasive carcinoma.
These results suggest that alteration of adherens junctions leads to AJCs defects in the biliary epithelial cells of Vdr −/− mice submitted to biliary-type liver injury.
27 These results therefore suggest that the bile duct rupture observed in Vdr −/− mice is related to a loss of adherens junctions in biliary epithelial cells caused by E-cadherin truncation.
Moreover, these observations suggest that the increased liver injury observed in these mice is related to the disruption of cell-cell interactions between biliary epithelial cells.
Liver tissue section immunostained for E-cadherin were then analyzed by an investigator unaware of the mouse genotype (D.F .. Typical bile ducts displayed membranous E-cadherin expression between biliary epithelial cells.
In sham-operated mice of both genotypes, E-cadherin expression was evident at the membrane of biliary epithelial cells.
Studies of mouse and human embryonic development indicate that they are common progenitors of mature hepatocytes and biliary epithelial cells, the lineage commitments of which are determined around the mid-gestation stage [9].
Finally, endotoxins may directly favor the disruption of biliary epithelial cell AJCs, 41 a feature that has been documented in a mouse model of PSC.
Administration of a single large dose of ANIT (300 mg/kg body weight) to mice leads to rapid (15 to 24 hours) cholestasis induced by severe destruction of biliary epithelial cells and periportal hepatocellular necrosis [ 37].
Vdr −/− mice displayed more bile duct ruptures that paralleled defective E-cadherin staining, suggesting that VDR is required in biliary epithelial cells to ensure cell-cell interactions.
