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The resulting compilation contains 1290 probesets in the human and 1029 probesets in the mouse array datasets.
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The mapping of transcripts or genes between the mouse signature and the human tumor array datasets was made on the Entrez Gene identifier; where multiple human array probe sets referenced the same gene, the probe set with the highest variation represented the gene.
Retrospective analysis of gene array datasets of the striatum of HD patients and transgenic mouse models of HD confirms that Crym mRNA levels are reduced in HD (31, 32).
To demonstrate the biological validity of tissue meta-profiles, we carried out a principle component analysis of a mouse tissue expression dataset which had been summarized from more than 3000 Affymetrix array datasets available in GENEVESTIGATOR.
A number of array datasets in the GEO database provide evidence that Tecta is expressed at low levels in the mouse brain, and the Allen brain atlas indicates there may be expression in several locations in the brain (Tecta RP_060315_04_H11).
We also developed methods to opportunistically discover small, disruptive CNVs within the large and growing diagnostic array datasets.
A dataset that was compiled from publicly available data and used in a previous study (by Jupiter and VanBuren) [24] of more than 16,000 genes represented on 2,145 mouse array experiments conducted on Affymetrix GeneChip® mouse genome 430 2.0 arrays was analyzed in this work to study gene expression profiles.
The Entrez Gene identifier was used in mapping genes across the array datasets.
Our selected probes can assist future analyses of other exon array datasets.
FitSNPs were derived through extensive analysis of public array datasets [28].
Array datasets were generated in duplicate for liver and kidney of all control and treated animals.
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