Sentence examples for mouse apoE provides from inspiring English sources

Consequently, mouse apoE provides a suitable system for exploring the role of the stability of the entire protein molecule.

Finally, along with apoEKO mice, knockin mice expressing human apoE isoforms in place of endogenous mouse apoE have provided insights into how quantitative and qualitative genetic alterations interact with the environment in the pathogenesis of complex human diseases.

A pET32a expression vector containing the cDNA of mouse apoE was kindly provided by Dr. Karl Weisgraber.

The data in Table 1 provides some insights into the effects of the above mutations on the structures of human and mouse apoE.

We purified apoE and apoJ from primary cultures of mouse astrocytes, which were derived from transgenic mice expressing human apoE isoforms in the absence of mouse apoE.

This allows the study of apoE without interference from the endogenous mouse APOE gene.

To create a model to study apoE in brain, we have generated APOE transgenic mice using microinjection of allele-specific human genomic fragments to establish founders which were then bred to APOE knockout mice lacking a functional mouse apoE protein.

To investigate the role of human apolipoprotein E (apoE) on Abeta deposition in vivo, we crossed PDAPP mice lacking mouse Apoe to targeted replacement mice expressing human apoE (PDAPP/TRE2, PDAPP/TRE3, or PDAPP/TRE4).

In this study, we used transgenic, targeted replacement mice that carry the three human APOE isoform-defining sequences at the mouse APOE chromosomal location and express the human APOE isoforms.

Specific ELISA for mouse apoE and human apoE.

APOE transgenic mice may provide an appropriate model to examine the mechanistic basis for the differential effects of human apoE isoforms in acute central nervous system injury.