Sentence examples for mouse animal models from inspiring English sources

Although this model is based on data obtained in cell lines, and should be verified using a more physiological context, as knock-in mouse animal models [61], [62], we consider that it proposes an attractive possibility worthy to be investigated.

Previous observations made using mouse animal models suggest that MCP-1 and chemokine receptor 2 might be involved in the etiology of AMD and that macrophage dysfunction may have a central role in the early stage of AMD development [37], [38].

A major motivation for performing this experiment was the observation that although SCID mouse animal models are the most commonly used in research on drug development, an X-SCID immunodeficient rat model would complement mouse models through the additional advantage of being employed for testing the pharmacodynamics and toxicity of potential therapeutic compounds.

We tested three separate cases, hypoxia, Diabetes drug and Alzheimer by using gene expression profiles of mouse animal models.

In this paper, we presented data only from mouse animal models, for the mouse was the main model for common human diseases.

More recently, retinol binding protein-4 (RBP4), an adipocytokine linked to insulin resistant states in mouse animal models and in humans [ 7, 8] and predicting the development of type 2 diabetes [ 9], has been associated to endothelial dysfunction in new-onset type 2 diabetes [ 10].

To further study antiviral function in vivo, the efficacy of ribavirin against H7N9 infection was then tested in a mouse animal model.

Due to poor adenoviral infectivity and replication in mouse tumor cell types compared with human tumor cell types, use of human-type adenoviral vectors in mouse animal model systems was limited.

Additionally, we reasoned that the mouse animal model would allow us to elucidate the underlying cellular and molecular mechanisms that are responsible for the generation of tissue in peritoneal cavity.

To address these issues, we initially examined the role of TR1 in a mouse lung cancer cell line and a mouse animal model and observed that reduction of TR1 levels reversed numerous malignant properties including tumorigenecity [16].

Mouse animal model studies have shown that, in the small intestine, EphB receptors mediate intestinal stem cell proliferation [21] as well as epithelial cell migration and organization along the crypt-villous axis [5].