To date, similar experiments have proved successful in rat, mouse, and pig models.
These studies demonstrate that the function of m6A methylation on pluripotency could be highly conserved between mouse and pig.
Here, by engineering reprogramming factors to a destabilizing protein domain, we achieved inducible generation of mouse and pig iPSCs.
So far Dr. Grikscheit has concentrated on growing rat, mouse and pig intestinal tissue in laboratory animals.
Interesting, we further found that nearly half of the editing events occurred in the seed region in both mouse and pig.
Of the 22 mutants identified as attenuated in either animal model, eight insertion mutants caused no mortality in both mouse and pig models.
Summary, we depicted the overall profile of miRNA editing during spermatogenesis in mouse and pig and reveal miR-34c may play its roles through miRNA editing.
The organization, composition and three-dimensional architecture of the pancreatic ECM were analysed in mouse and pig by three different techniques.
Hammad, S. et al. Protocols for staining of bile canalicular and sinusoidal networks of human, mouse and pig livers, three-dimensional reconstruction and quantification of tissue microarchitecture by image processing and analysis.
To develop a tissue-engineered bioartificial liver (BAL), perfusion cultures of mouse and pig fetal liver cells (FLCs) immobilized within a three-dimensional (3D) porous scaffold were performed utilizing a packed-bed reactor system.
The rat insulin 2 gene (Ins2) promoter, widely used to achieve transgene expression in pancreatic β-cells of mice, also directs expression to extrapancreatic tissues and performs poorly in isolated pancreatic islets of human, mouse, and pig.
