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Here, we evaluated NIR FPs of the iRFP protein family, which were reported to be the brightest in non-neuronal mammalian cells, in primary neuronal culture, in brain slices of mouse and monkey, and in mouse brain in vivo.
Somewhat surprisingly, compound 26 was only weakly active in vitro against mouse and monkey tumor cell lines even though it was a potent inhibitor of NAMPT enzymes derived from these species.
Mouse and monkey models detail viral attack on the placenta and the brain.
Indeed, SSR504734-related radioligands such as 11 C]showedowed high brain uptake and a consistent accumulation with the GlyT1 distribution in the mouse and monkey brain [23].
Table 3 Absorbed radiation dose estimates for 64 Cu-MM-302 based on mouse and monkey kidney micro-dosimetry Kidney sub-region Mouse (mSv/MBq) Squirrel monkey (mSv/MBq) Papillae 0.11 0.22 Pelvis 0.61 0.65 Medulla 0.05 0.16 Cortex 0.04 0.15 Total kidney 0.07 0.17. Figure 2c summarizes the results of multiple independent studies in which mice (n = 15) were imaged following injection with 64Cu-MM-302.
They were chosen for the study largely based on the finding that optineurin is prominently expressed in the RPE tissue in mouse and monkey eyes [10], [34].
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Modified NEMA NU2-2001 protocols were used in order to simulate performance based on mouse, rat and monkey imaging conditions.
The neurons survived, formed new connections and restored lost movement in mouse, rat and monkey models of the disease, with no sign of tumour development.
The residues Asn123 β4) and Glu264 are conserved among human, mouse, rabbit and monkey (Figures S6 and S7), this functional data thus may be applicable in other hosts.
CX3CL1 is the only known member of the CX3C subfamily in human, mouse, rat, and monkey.
The expression of endocanΔ2 was then studied in mouse, rat and monkey lungs cDNAs.
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