The mouse analogue of the human Onuf's nucleus was determined according to the mouse spinal cord atlas (Watson et al., 2008).
Further analysis of the lumbosacral region of the spinal cord showed an early loss of neurons in the mouse analogue of Onuf's nucleus that was associated with transgenic oligodendroglial αSYN overexpression and further augmented at 12 months.
To demonstrate the capacity of EL to elicit expression of IL-8 in vivo, MIP-2 (a mouse analogue of IL-8) was measured in mice upon adenovirus-mediated EL overexpression.
Here, mouse analogues of human Gaucher disease with tissue involvement, including the presence of Gaucher cells and excess GC storage, were used to compare two preparations of mannosyl-terminated GCases for treatment effects and dose response as well as pharmacokinetics and pharmacodynamics.
Previous work has demonstrated that rodent ERPs share many specific similarities with humans, including mouse analogues of the N100, MMN, and P300 components that share stimulus and pharmacologic response properties with the corresponding human components [ 42, 43].
The animals were divided into the following treatment groups: group 1 (10 mice), control, vehicle solution; group 2 (10 mice), analogue AN-215; group 3 (five mice), unconjugated mixture of the cytotoxic radical AN-201 and BN antagonist RC-3095.
16 26 Alexa-fluor 647 conjugated dextrans were administered to the mouse intravenously as an analogue of the fluorescein used in our human studies.
Numerous human analogues of the mouse genes have been identified, such as an analogue of the mouse Mash2 gene, which is important for the spongiotrophoblast development.
Breeding laboratory mice on food of different consistencies mimicked a natural variation in feeding ecology, whereas mice affected by the murine analogue of the Duchenne muscular dystrophy provided a case of pathological modification of the mastication process.
In vitro stimulation of splenocytes from CD47−/− and C57BL/6 mice with PBS-57, an analogue of αGal-Cer 29, demonstrated that CD47 was required for optimal production of IFN-γ by iNKT cells, measured as percentage of responding cells or as integrated MFI (iMFI) 30((Fig. 1I and data not shown).
For a full understanding of spatial cognition it is important to understand how animals represent and use space in all three of its dimensions; accordingly, the present experiment investigated whether mice could learn a 3D analogue of a common 2D laboratory spatial task, the radial maze.
