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The leptin-induced STAT-3 phosphorylation was found to be higher along with an upregulated hypothalamic expression of the Ob-R at 14 - 18 months of mouse age compared with 2 months of age [41], indicating increased leptin sensitivity with aging in the mouse brain.
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AKT phosphorylation was sustained at a higher expression level in liver tissue in MTMR14 KO mice at every age compared to WT littermates (Fig. 8i).
Quantitation of changes in epithelial acini wall thickness demonstrated significant differences in transgenic mice over a year of age compared to aged wildtype controls (Figure 2I).
Strikingly, HGF was upregulated +5.7-fold in mdx p65+/− mice at 4 weeks of age compared with WT mice.
However, no significant difference in brain atrophy or neuronal loss was observed in these mice at 6 months of age compared to wild-type mice.
We observed an increase in body and liver weight in HFD-fed mice at 20 weeks of age compared with ND-fed mice (see Supplemental Material, Table S3).
However, levels of total and phosphorylated tau were significantly reduced in DAPK1 KO mice at 12 22 months of age compared with those in WT mice.
The mRNA level of ARRDC3 was increased in the hippocampus of Tg6799 (MT) mice at 4 months of age compared to their littermate (LM) controls.
β-cell apoptosis in Hq mutant mice was increased at all ages compared to WT (Neonates P0: 0.4% in Hq mutant mice versus 0.2% in WT.
Indeed, Siglec-E-deficient mice exhibited accelerated signs of aging compared to littermate controls.
In addition, Park [ 34] reported that lentiviral vector transduction efficiency and transgene expression were significantly enhanced in adolescent (3 1/2 weeks of age) mice compared to older (7 weeks of age) mice.
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