For CCl4-induced chronic liver injury mouse model (n = 12), CCl4 in olive oil was intraperitoneal administration twice per week for 6 weeks, mice administrated with olive oil was referred as normal controls (n = 12), according to a previous study36.
Consistently, we also observed significant rescue of GalN/LPS-induced decreased autophagy in liver tissues of mice administrated with 30 mg/kg M1 (Fig. 4d).
However, the overall gut microbiota structure and diversity in CP mice administrated with IOP was ambiguous.
(B E) The wildtype mice administrated with NGF-neutralizing antibody or control IgG were subject to cold challenge.
HIV specific delayed type hypersensitivity response and CTL activity were enhanced in mice administrated with genetic murine IL-2 and antigen intranasally (Xin et al., 1998).
Moreover, murine lymphoid cells from mice administrated with genetic IL-15 and antigen yielded increasing production of IFN-γ and reducing secretion of IL-4.
Antigen specific systemic/mucosal antibodies were significantly enhanced in mice administrated with replication-deficient adenovirus vector expressing murine BAFF and heat-killed P. aeruginosa intranasally, reducing murine mortality under lethal dose challenge of P. aeruginosa (Tertilt et al., 2009).
The levels of pulmonary APCs and cytokines, including IFN-γ and IL-12p40, were significantly elevated in mice administrated with recombinant RSV expressing murine GM-CSF intranasally (Bukreyev et al., 2001).
As shown in Figure 6D, there was a significant reduction (approximately 10%) of Ter119+ population (representing erythroid cells) in spleens from mice administrated with GO compared to the control (P < 0.05), indicating that GO exposure diminished erythroid cells in spleen.
As shown in figure 7, blockade of the A2AR caused an increase in serum and lavage IL-6 and TNFα levels to similar levels found in infected mice administrated with vehicle alone.
