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However, in hevin null mice, accelerated wound closure was in part attributed to its de-adhesive and anti-migratory function for dermal fibroblasts [ 34], whereas in SPARC null mice, acceleration was attributed to decreased collagen content rendering the skin more susceptible to cell contraction [ 33].
The Glud1 over-expressing mouse does show an acceleration in the rate of aging-associated changes observed in normal brain [ 14], yet some of the neurobiological functions and molecular pathways altered in the transgenic mouse brain differ significantly from those altered during aging.
In another study, MMTV-myr-Akt1 transgenic mice were crossed with MMTV-c-ErbB2 transgenic mice and a similar acceleration in tumor development was observed.
The co-injection of PCa cells with conditioned fibroblasts (WI38C) in immunodeficient mice determined an impressive acceleration in tumor growth.
Tumor quantification of K-ras LA1/+ ; Msh2 −/− mice demonstrated a significant acceleration in lung tumor development (Table 1), with a higher incidence of adenocarcinomas and a statistically significant increase in adenoma formation as compared to all other groups of mice.
However, there was less disease acceleration in lpr mice compared with MRL+/+ mice, likely due to the fact that environmental factors are less critical for disease induction when there is strong genetic susceptibility.
Using increasing doses of the protozoan parasite Trypanosoma cruzi to infect C57BL/6 mice, we observed a significant acceleration in the timing of parasitemia without an increase in mouse susceptibility.
Repeated subcutaneous administration of the chimeric peptide to mice resulted in a significant acceleration in longitudinal growth, whereas CNP(1 22) did not.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com