The generation of APP/PS1KI mice (a generous gift by Dr. Laurent Pradier, Sanofi-Aventis, Paris) has been described previously [ 8].
Recombinant soluble mouse BAFF (Apotech, Switzerland) was used to generate a standard curve and sera from BAFF Tg mice (a generous gift from Dr. J. Gommerman) as a positive control.
Cln1 −/− mice (a generous gift from Dr. Sandra L. Hofmann, University of Texas Southwestern Medical Center at Dallas, Dallas, TX) were generated by gene targeting in Embryonic Stem cells as previously described.
Conventionally raised TNFΔARE mice (a generous gift from Kollias G., Institute for Immunology, Biomedical Sciences Research Center "Al.
Experiments were performed on a total of 12 geriatric female B6/C3H mice (a generous gift from Rinat-Pfizer, San Francisco, CA, USA).
Arthritis was induced in male, six-week-old C57Bl/6 mice (Harlan, Indianapolis, IN, USA) by intraperitoneal injection of 100 μl serum from K/BxN mice (a generous gift from Mohini Gray) as described [ 43, 44].
The ND2 SmoA1 mouse line (the SMO mouse) was a generous gift from Fred Hutchinson Cancer Research Center (Seattle, WA, USA) and was generated as previously described (Hallahan et al, 2004; Hatton et al, 2008).
Tissues from the MMTV-neu mouse were a generous gift from Dr. Robert S. Weiss, Cornell University, and the MMTV- Wnt-1 hyperplastic mammary glands and tumors were a gift of Dr. Louise R. Howe, Weill Cornell Medical College.
Polyclonal antibodies that were generated against RVFV in mice were a generous gift of Dr. P. Rollin (CDC).
Prx1Cre and Sox9 f/f mice were obtained from the Jackson Laboratory; Rbpjκ f/f mice were a generous gift from Dr. Tasuku Honjo (Kyoto Graduate School of Medicine, Japan).
