Sentence examples for mouse ESCs including from inspiring English sources

Knockdown of the Fam40b compromises the differentiation of mouse ESCs including cardiomyocytes.

We employed five time series microarray datasets of mouse ESCs in this study, including a dataset for retinoid acid induced differentiation [ 15] and four datasets for spontaneous differentiation of four ESC lines (three lines from [ 22]; one unpublished, S.Z. and W.H.W, manuscript in preparation).

The regulatory network of ESC including a few crucial transcription factors is also revealed by well-defined mouse microarrays.

We also observed that SALL4 was able to bind the promoter regions of these two genes in either mouse ESCs, two human AML samples including M0 (FAB classification) or AML transformed from CML (chronic myeloid leukemia) using ChIP-on-ChIP assays (data not shown).

To determine whether miRNAs are expressed in ESCs and reprogrammed pluripotent cells at similar levels, expression profiling of all known miRNAs was performed on mouse ESCs and reprogrammed pluripotent cells, including iPSCs, NT-ESCs and NT-iPSCs.

As mentioned above, previous studies have described a role for Polycomb repressive complexes (PRCs) in silencing of INK4-ARF in several non-malignant cell types including fibroblasts, mouse ESCs, and adult stem cells (Jacobs et al., 1999; Molofsky et al., 2005; Bracken et al., 2007; Li et al., 2009).

In the mouse model, Tsai and de Pater et al. reported that Gata2−/− mouse ESCs are capable of producing multipotential CFCs including granulocytes albeit in a much smaller number compared to wild-type ESCs [ 10, 14], and Gao et al. documented the abolished CFC potential of Gata2−/− AGM cells.

Genes involved in the establishment and maintenance of the pluripotent state, including Oct3/4 (Pou5f1), are hypomethylated in mouse ESCs (Hattori et al., 2004; Imamura et al., 2006).

Stage-specific embryonic antigen-1 (SSEA-1), a marker for both mouse ESCs and embryonic carcinoma cells (ECCs), is also included in this group, and it contains Le x and mediates homotypic adhesion related to compaction or autoaggregation [ 25].

We observe this H3 cleavage product in spite of the use of protease inhibitors during histone isolation, including a protease inhibitor cocktail (Roche), which inhibits enzymatic cleavage of H3 in human ESCs [ 26], and E-64, which inhibits cathepsins, including Cathepsin L, which cleaves H3 in mouse ESCs [ 11].

Mouse ESCs (mESCs) can be maintained in defined media that includes two kinase inhibitors (known as "2i") to block the MEK/ERK and GSK3 signaling pathways (Ying et al., 2008; reviewed in  Wray et al., 2010).