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Among health care personnel who did not respond after a primary series, 67.6% mounted a protective response up to three additional doses (11).
Immune responses to wtOMV vaccines especially in infants are largely directed toward the PorA protein; only about 10% of infants mounted a protective antibody response against the Chilean epidemic strain following vaccination with either the Cuban or Norwegian wtOMV vaccine.
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Infected individuals may mount a protective immune response for each specific serotype but only short-term heterologous protection against the other serotypes [ 4].
The autoimmune reaction described above is a negative effect of the immune response to cancer cells, but it does indicate that the body can mount a protective response to cancer.
In the absence of inhibitory maternally derived antibody (MDA), pups and kittens are capable of mounting a protective immune response at an early age.
Carlton Cyrus Ward and Zach Morris demonstrate, turning a chalkboard into a tightrope and mounting a protective barricade made from rows of desks.
Nuclear translocation of NF-κB induces transcription of proinflammatory cytokine genes essential to mounting a protective immune response and host defense.
Moreover, complementation of ΔphoQ with a wild-type allele not only restored the ability of rapidly growing Salmonella to mount a protective ATR, but also reestablished its sensitivity to NO.
Mice with complete inactivation of TNF or TNFR1 gene are unable to mount a protective response against various pathogens [15], but develop ECM, while TNFR2 deficient mice are resistant to ECM development [16].
Conversely, Edelmann and colleagues have reported that in the absence of TLR3 signaling, mice can still mount a protective immune response following challenge with various viruses, including lymphocytic choriomeningitis virus (LCMV), vesicular stomatitis virus (VSV), MCMV, and reovirus, resulting in unaffected viral clearance and no increase in viral pathogenesis [22].
In fact, not all vaccine recipients mount a protective response, even after receiving the recommended immunization schedule.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com