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Exact(4)
Irrespective of the CHMP criteria, it is interesting that 87.5% of the subjects who received two doses of either the 10 or 20 µg VLP vaccine mounted a detectable HI response and 95.8% mounted detectable MN responses.
A recent study by Yang et al showed that persistent HBV carriers mounted a detectable HBV-specific IFNγ response to a HBV-derived DNA vaccine and this response was observed for at least 40 weeks as a function of CD4+ memory T-cells [43].
We also probed purified M1 protein by ELISA, and as expected, neither the mouse sera nor lamprey mounted a detectable antibody response.
In order to demonstrate PSA specificity of IFN- γ production, the nonspecific response against HSA was assayed in parallel for each sample No patient mounted a detectable PSA-specific IFN- γ response prior to vaccination.
Similar(56)
In spite of the excellent response to boosting in general, 3% of boosted participants did not mount a detectable antibody response following a booster dose of HBV.
Our own studies indicate that B. marinus tadpoles did not mount a detectable antibody response to a widely used and well characterised immunogen, ovalbumin, to which adult B. marinus did respond.
While most of these studies have been carried out in Xenopus, limited studies indicate bullfrogs are capable of mounting a detectable antibody response to an antigen, but apparently not to influenza virus despite repeated inoculations and a substantial and anamnestic response to bacteriophage T7 [36].
It is possible that these individuals may have been primary non-responders as a study in two rural Gambian villages showed that two months after the last infant vaccination, 5% of children did not mount a detectable anti-HBs response and were therefore considered primary non-responders to the HBV vaccine [12].
In individuals who mount a detectable humoral immune response, HPV type-specific serum antibodies are an indicator of past exposure.
For instance, only about 50 70% of women with persistent cervical HPV infection mount a detectable antibody response, and most women with transient infection do not have detectable antibodies or have them only for a short time 131– 131.
Since CNS involvement in children can occur quite early (within a few days) after a tick bite, a previously Borrelia-nonexposed host might not be able to mount a detectable antibody response against the pathogen in such a short time [ 49].
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