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In our paradigm, we show an increased propensity for regrowth in L6 axons, with the majority of other cortical axons unable to mount a regenerative response.
Identifying and characterizing these processes will be important for understanding how the decision to mount a regenerative response occurs.
These studies suggest that if presented with the appropriate triggers and environmental conditions, CNS neurons can mount a regenerative response.
It is therefore likely that the TGF-β signalling pathway is not the only player involved in the decision to mount a regenerative response.
Following peripheral nerve injury, SCs mount a regenerative response involving coordinated dedifferentiation, proliferation and redifferentiation that supports axonal regrowth and helps restore peripheral nerve function [ 1].
The ability of these normal cell-renewal systems to mount a regenerative proliferative response was evaluated by radioisotopic, morphological and gravimetric techniques 4 months after drug treatment.
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In asexual animals they are the only cells capable of undergoing cell division and as such can be readily eliminated by gamma-irradiation to produce an animal that can survive for several weeks, but is incapable of mounting a regenerative response upon wounding.
Aguayo's work and more recent studies [ 4– 6] have all demonstrated that supraspinal neurons (neurons arising in the cerebral cortex or brainstem and which project their axons caudally into the spinal cord) are actually capable of mounting a regenerative, albeit brief, and response following injury, when provided with the proper environment.
Unlike mammals, lower vertebrates such as zebrafish mount a strong regenerative response following cardiac injury.
Recovery from injuries to the central nervous system, including spinal cord injury, is constrained in part by the intrinsically low ability of many CNS neurons to mount an effective regenerative growth response.
As such, an intimate and dynamic epithelial-mesenchymal cross-talk, which is also essential during lung development, is required for normal homeostasis and to mount an appropriate regenerative response after lung injury.
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