Sentence examples for mount a proinflammatory from inspiring English sources

Indeed, monocyte deactivation is thought to be responsible for the impairment in antigen presentation and the decreased capacity to mount a proinflammatory reaction upon a secondary bacterial challenge [133].

At an intermediate level, redox-sensitive mitogen-activated protein kinase (MAPK) and nuclear factor kappa-light-chain enhancer of activated Bcells (NF- κB) cascades mount a proinflammatory response.

But without the rapid clearance of myelin debris or toxic elements from the brain, microglial cells can react differentially and mount a proinflammatory response that is detrimental for neurons and astroglia, resulting in demyelination, synaptic dysfunction and ultimately neurodegeneration (46).

Interestingly, the expression of CXCL1/2 and TNF- α also increased significantly when uninfected keratinocytes were stimulated with the cytotoxic Fas antibody showing their ability to mount a proinflammatory response mediated through the Fas-dependent pathway.

Indeed, monocyte deactivation is thought to be responsible for the impairment in antigen presentation and the decreased capacity to mount a proinflammatory reaction upon a secondary bacterial challenge [ 133].

Monocytes from septic patients are mainly characterized by a decreased capacity to mount a proinflammatory reaction upon a secondary bacterial challenge and by impairment in antigen presentation capacity, most probably due to the lowered expression of major histocompatibility complex class II molecules.

We hypothesised that surgical incision of the peritoneal wall in mice would be a potent stimulus for the recruitment of monocytes, particularlythe inflammatory Gr-1Hi subset [ 2], to the peritoneal space where they would be capable of mounting a proinflammatory response to subsequent septic challenges.

Once initiated, differentiating human endometrial stromal cells (HESCs) mount a transient proinflammatory response that renders the endometrium receptive to implantation.

They suggested a strong suppressive direct effect of low pH stress on the ability of alveolar macrophages to mount an adequate antibacterial proinflammatory response following TLR2 and TLR4 activation.

In summary, our findings demonstrate a strong suppressive direct effect of low pH stress on the ability of aMØs to mount an adequate antibacterial proinflammatory response following TLR2 and TLR4 activation.

After intraperitoneal injection of heat-killed pneumococci in vivo, however, TLR2KO mice displayed unaltered proinflammatory cytokine gene expression in their spleens, whereas MyD88KO mice had virtually completely lost their ability to mount a splenic cytokine response [ 24].