Exact(5)
Additionally, another retrospective case series showed that failure to mount a febrile response within the first 24 hours was associated with increased mortality [ 33].
Thirdly, C5-deficient mice or those pretreated with a C5a receptor antagonist are unable to mount a febrile response to intraperitoneal endotoxin challenge [ 14].
The clinical studies however suggest inability to mount a febrile response to be associated with increased mortality in patients with sepsis [ 18- 20].
However, perhaps because of this study and others like it [ 13- 15], it is thought that older patients are less likely than younger patients to mount a febrile response to infection or bacteraemia.
In a murine model COX-2 knockout mice were unable to mount a febrile response to endotoxin, and in humans COX-2 selective inhibitors were shown to reduce fever [ 23, 24].
Similar(55)
Despite patients mounting a febrile response, temperature control was achieved and maintained successfully.
Possibly, some reported symptoms were not caused by bacterial infections, or some children were not mounting a febrile response despite being infected.
Patients with cirrhosis have low baseline blood pressure, higher baseline heart rate, higher baseline breathing rate, and tend to not mount a vigorous febrile response.
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