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We set out to identify neural circuit mechanisms that regulate motor variability during motor skill learning.
For example, the title might be: "A neural circuit mechanism for regulating motor variability during song learning in zebra finches".
[Editors' note: what now follows is the decision letter after the authors submitted for further consideration.] Thank you for sending your work entitled "A neural circuit mechanism for regulating motor variability during skill learning" for consideration at eLife.
[Editors' note: this article was originally rejected after discussions between the reviewers, but the authors were invited to resubmit after an appeal against the decision.] Thank you for choosing to send your work entitled "A neural circuit mechanism for regulating motor variability during skill learning" for consideration at eLife.
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Impairments in motor automaticity cause patients with Parkinson's disease to rely on attentional resources during gait, resulting in greater motor variability and a higher risk of falls.
Reviewer #1: In this paper, Santos et al. investigated whether motor variability in the outcome-relevant dimension specifically reduces during learning, and whether such reduction is mediated by neuronal activity in corticostriatal circuits.
The current paper relates changes in RA circuitry during initial learning and development to the regulation of motor variability.
Vocal motor variability and exploration on multiple time scales likely facilitates the refinement of vocal output during development, and the maintenance of previously learned, ultra-precise, motor patterns throughout life.
Kinematic motor variability is extensively studied in occupational, clinical and sports biomechanics, but the consistency of most motor variability metrics have never been reported.
Motor variability was assessed using nonlinear metrics based on information theory and recurrence quantification analysis.
This is achieved by a relatively complex motor unit pool model of parallel Hill-type motor units that model realistic motor variability.
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