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Differential motor unit responses were observed between CNTF genotypes at force levels utilized in daily activities.
The result was an estimate of the number of single motor unit responses that made up the maximal EMG response.
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The maximal EMG response was then divided by an estimate of the average single motor unit response.
The basic principle underlying the four MUNE techniques they simulated is the division of the total muscle response by an estimated mean single motor unit response (SMUP).
The peak-to-peak amplitude of each individual motor unit response was calculated by subtracting the amplitude of the prior response.
Davidson and Ludlow (1996) attributed the increased duration of motor unit response to the inefficiency of collateral sprouting which they noted begins to decrease in one year.
The total motor unit response was determined by supramaximal stimulation of the peroneal nerve axons to produce a maximal M-wave.
In the future, these biomarkers can be applied in different mouse models to understand the pattern of motor unit loss and response to treatment.
These studies suggest that maximal motor unit firing rates increase in response to dynamic but not isometric resistance training.
Houk & Henneman [ 21] also found the GTOs to exhibit a saturation effect where by the responses to one motor unit and that of a second motor unit did not sum algebraically.
Houk & Henneman [ 21] considered the variable response of GTO discharge to tension changes to be due to differences in motor unit recruitment.
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