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The statistical significance levels for direct and calculated motor unit measures are presented in Table 3. Significant differences by CNTF genotype and the interaction between CNTF genotype and muscle force generation were present in essentially all models while controlling for age and gender.
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Motor unit measurements were obtained during contraction levels of 10, 20, 30, and 50% of MVC for the Baltimore Longitudinal Study of Aging cohort, while measures were available only for 10 and 30% MVC for the exercise intervention cohort.
Last year, researchers at the Canadian Centre for Activity and Aging, for instance, examined muscle tissue from older competitive runners, checking for the density of their motor units, a measure of muscle health.
MURI is an estimate of the relative number of motor units being measured by the active recording electrode.
45 Therefore, the findings of significant reduction in estimated functional motor units (as measured by MUNE) in SMNΔ7 mice are particularly interesting and important as these findings may suggest that function does not parallel morphology in this rapidly progressive model.
The techniques described here measure motor unit function in a preclinical model of SMA using methods that parallel those predicted to be used in future clinical trials.
FD quantifies the local concentration of muscle fibers within a motor unit and is a sensitive measure of reinnervation.
Computer simulations of motor unit action potentials (MUAPs) as measured by a concentric needle (CN) electromyography (EMG) electrode in normal motor units (MUs) indicated that the MUAP amplitude is determined mainly by the proximity of the electrode to the closest muscle fiber.
Multipoint incremental motor unit number estimation as an outcome measure in ALS.
The purpose of this study was to measure vastus medialis motor unit (MU) properties in participants with knee OA, during submaximal isometric contractions.
The potential of these measures includes the ability to assess the output of the motor unit in vivo and the ability to provide parallel measures in mouse and human and thus predict outcomes in early clinical trials.
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