Sentence examples for motor unit loss from inspiring English sources

Hegedus, J., Putman, C. T. & Gordon, T. Time course of preferential motor unit loss in the SOD1 G93A mouse model of amyotrophic lateral sclerosis.

Conclusion: Compared with nulliparous control subjects, patients with genuine stress urinary incontinence and pelvic organ prolapse had changes in the levator ani and external anal sphincter consistent with either motor unit loss or failure of central activation, or both.

Motor unit loss (denervation) occurs with aging and is a major contributory factor in sarcopenia (Doherty et al., 1993).

Axotomy at P2 results in statistically significant (p < 0.05) motor unit loss in both EDL and soleus in all age groups.

These studies confirm features of preserved neuromuscular function in the early postnatal period and subsequent motor unit loss in SMNΔ7 mice.

In the future, these biomarkers can be applied in different mouse models to understand the pattern of motor unit loss and response to treatment.

Aging is associated with a series of changes in the peripheral nervous system and the motor units: loss of spinal motoneurons, decrease in the conduction velocity of axons, loss of muscle fibers, increase in the size of motor units and reorganization of motor units [18], [19].

By 24 weeks, at which point we observed a reduction in motor unit survival but no loss of muscle force, there was a significant decrease in motor neuron survival compared with wild-type littermate controls (P<0.05).

This evidence indicates that loss of motor unit function is the result of degenerative events in the periphery and not motor neuron cell death [9], [10].

Since degeneration of motor terminals and peripheral motor axons precedes motor neuron cell death [6] [8], adverse interactions between TSCs and motor terminals or between axons and myelinating cells could be of direct importance for determining loss of motor unit function in B6.SOD1 mice and conceivably trigger more widespread motor neuron degeneration.

We have shown that these techniques can identify loss of motor unit function in the SMNΔ7 mouse model mirroring those seen in patients with SMA.