Motor timing processes at local levels in utterances are related to fluency, possibly involving cerebellar mechanisms.
This suggests abnormalities in motor timing were predominantly related to deficient motor timing processes and not to general deficient motor functioning.
The first developmental fMRI study of motor timing processes found that during sensorimotor synchronisation of 6 s, 8 adults performed better than 9 children and adolescents between 10 and 17 years and showed increased activation in anterior and posterior cingulate, right IFC, putamen and left inferior parietal lobe.
For example, timing functions, including motor timing, time estimation and temporal discounting are further refined throughout late childhood and adolescence [ 9– 12].
Therefore, it remains unclear whether the variability in motor timing is primarily due to variability of motor processes, or due to variability of timing processes or both.
In summary, the study aimed at assessing timing processes with varying demands on the motor system in presymptomatic (pHD), symptomatic HD (HD) and healthy controls.
The aim of this study was to assess to assess timing processes with varying demands on the motor system in presymptomatic (pHD), symptomatic HD (HD) and healthy controls to estimate if the assessment of timing of timing functions may be of clinical value in the diagnosis of HD.
While some of these additional areas would traditionally be associated with motor-related processing, several of these regions have been activated in recent studies on timing processes [e.g., Bengtsson et al., 2009; Grahn and Brett, 2007; Grahn and Rowe, 2009] which may explain their sensitivity to synchronous timing here.
Based on the findings of neurobiological and neuroanatomical alterations in ASD and the functional neuroanatomy and neurobiology of different action control functions, we emphasize that changes in action control processes, including response inhibition, conflict and response monitoring, task switching, dual-tasking, motor timing, and error monitoring, are important facets of ASD.
Changes in "timing processes" are found in HD, but no study has varied the degree of motor demands in timing functions in parallel in HD.
Furthermore, acute methylphenidate normalized the underactivation in right IFC that was observed in ADHD patients under placebo compared with healthy control subjects during inhibition and timing processes [see also (23,24 ], which has also been observed previously during interference inhibition (17), motor inhibition (18,23), WM (72), and TD (4) (Table S2 in Supplement 1).
