In contrast, cisplatin, carboplatin plus paclitaxel and oxaliplatin are well known for inducing chronic neuro-sensory toxicity in a high percentage of treated patients that typically present with chronic neuro-sensory symptoms and loss of sensation with motor function spared [ 2, 3, 14].
It causes a pins-and-needles sensation in the soles of the foot and legs, but spares motor function and usually does not weaken muscles.
In ADAR2 knockout mice, this motor neuron degeneration spares the oculomotor nucleus, suggesting that excitotoxicity is an important determinant of the selective vulnerability of spinal motor neurons, a finding that is further supported by the present study.
As part of all the upgrades, new motors will be ordered for all four clock faces, along with a spare motor in case one breaks.
When he wasn't drawing, he made his own toys, carving wooden puppets with his grandfathers' tools or devising a car race from a spare motor, string and tin cans.
Such results suggest a potential competition among motor tasks over spared neuronal circuitry.
The professional motorcycle racer, high-mileage tourer, or experienced motor cop uses spare, subtle motions to guide his machine; this guy sped up and slowed down and whacked his handlebars from side to side, clear evidence that he was either addicted to adrenalin or just plain stoned.
Some patients place a premium on cognitive versus physical abilities, and will forego treatment that will spare motor activity but will risk memory or personality, for example.
(M – P ) Motor neurons are spared at both cervical (M, N ) and lumbar (O, P ) levels following ablation of the V2b INs.
