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In another study, published in 2014 in the journal Translational Psychiatry, adult mice that received suramin showed improved social behaviors and metabolism, but no motor skill improvement.
This conclusion is based on our observation that while both 30 min and 3 hr post-injury groups had enhanced weight loss and motor skill improvement as a result of daily 400 mg/kg VPA injection, only the 30 min post-injury animals displayed improved spatial learning and memory.
However, when spindle density in the non-learning hemisphere (electrode C3) was subtracted from the learning hemisphere (electrode C4), representing the homeostatic difference following learning ([C4 C3]), a significant positive correlation was identified between the amount of offline motor skill improvement across the nap and the density of spindles (r = 65, p = 0.01; Figure 3c).
However, the design of the current study limits deeper interpretation of the observed results within the existing theories of sleep related motor skill improvement and memory consolidation (Siegel, 2001; Walker et al., 2002).
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Brown, R. M. & Robertson, E. M. Inducing motor skill improvements with a declarative task.
Tunovic, S., Press, D. Z. & Robertson, E. M. A physiological signal that prevents motor skill improvements during consolidation.
Until now, he says, the evidence has supported "narrow generalizability," in which learning one motor skill translates to improvement only in nearly identical tasks.
Motor skill learning usually comprises "fast" improvement in performance within the initial training session and "slow" improvement that develops across sessions.
We test the hypothesis that transfer of learning may fail because the learning and plasticity mechanism that adapts to the altered environment is different from the learning mechanism required for improvement of motor skill.
This might be due to a belief that the child's most normal motor skill must be used and the improvement of walking abilities might be prevented by the use of a wheelchair [ 7].
As with human motor skill learning, birdsong learning is characterized by gradual improvements in performance (similarity to the tutor song) and decreased motor variability (Tchernichovski et al., 2001; Ölveczky et al., 2011).
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