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In previous observations, we have reported that childhood cataplexy is not characterized solely by peculiar hypotonic features, but also includes motor overactivity compared with control subjects.
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For example, it has been demonstrated that OSA patients, that are at increased risk for cardiovascular events, have a cardiovascular control characterized by sympathetic overactivity compared to control subjects, both during night-time and day-time [26].
Similarly, children with ADHD or narcolepsy appear to use motor overactivity and fidgetiness to counteract their drowsiness [ 218- 220].
Impulsivity may contribute to motor (overactivity), cognitive (poor cognitive control), emotional (uncontrolled tempers) and interpersonal (social disinhibition) dysfunctions reported in patients with ADHD [ 14].
At onset, childhood narcolepsy with cataplexy is characterized by an abrupt increase of total sleep over the 24 h, generalized hypotonia and motor overactivity.
Traditionally, symptoms of hyperactivity have been assumed to decline by age and to change from gross motor overactivity as commonly observed in children, to a more subtle sense of inner restlessness in adults with ADHD [ 3].
Collectively, this quantitative anatomical evidence indicates that the MOs could be involved in more complex motor behaviors, such as motor planning9,24, compared with the MOp.
Both of the placebos improved motor function compared with a base line test.
a The hydrolysis activity of the native molecular motor compared to the reconstructed molecular motor.
Because the application of interest may involve multiple motors firing simultaneously, the heat flux from multiple motors is projected based on data collected for a single motor test, and compared to the data from two, three-motor configuration test.
Demographic information, motor and non-motor symptoms were compared between PD-C and PD-NC groups.
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