Sentence examples for motor neuron specification from inspiring English sources

Like Lim3, human LHX3/4 are TFs required for pituitary development and motor neuron specification.

However, their importance in animal development extends far beyond AP patterning, and includes functions from stem cell maintenance to motor neuron specification and leukemogenesis [5], [6], [7], [8].

There may be a defect in secondary motor neuron specification in srn, consistent with a role for Islet1 and Islet2 in secondary motor neuron formation and axonogenesis [32].

Lim3 is involved in complicated motor neuron specification networks, and is activated by Nkx6 and repressed by Even skipped (Eve) [10].

We correctly identify all major stages of the motor neuron differentiation process, from loss of pluripotency and development of positional identity to spinal motor neuron specification.

The only gene in this family that had been previously characterized is the ham-2 transcription factor, which is involved in C. elegans HSN motor neuron specification (B aum et al. 1999).

Pdu-Olig is, however, not expressed in this domain (it is expressed in the more medial NK6/ NK2.2-positive domain) and is therefore much probably not involved in motor neurons specification.

Olig2 is a bHLH transcription factor with a critical role in both motor neuron and oligodendrocyte specification.

In motor neuron disease, fibre-type specification and the metabolic weighting of bioenergetic pathways appear to be strongly influenced by both a differing degree of a subtype-specific vulnerability of neuromuscular synapses and compensatory mechanisms of fibre-type shifting.

A number of specific functions have been identified for these co-receptors at the cellular level within the developing CNS, including Shh-mediated commissural axonal guidance, neural progenitor specification, motor neuron maintenance and Shh-dependent proliferation of cerebellar granule neuron precursor cells (Allen et al., 2011; Izzi et al., 2011; Okada et al., 2006).

Another recent report demonstrates that Neurog2 phosphorylation at Ser231 and Ser234 by GSK3 regulates the specification of motor neuron subtypes but has no effect on the total number of neurons produced per se [38].