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Motor neuron size was also examined to quantitatively assess cell structure in motor neurons deficient for ß-actin.
Motor neuron size was assessed on the same sections by measuring the diameter at the largest point of all motor neurons with a minimum diameter of >20 µm using ImagePro software.
A simple explanation may be that the remaining 50% of NLK expression, AR phosphorylation, and mutant protein aggregation is enough to allow for the toxic effects of the mutant AR that directly result in decreased muscle fiber and motor neuron size.
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Laser settings were optimised for motor neuron cell body size.
Factors contributing to this selective vulnerability may include the post-mitotic nature of motor neurons, their large size, the high level of mitochondrial activity and their relatively low calcium buffering capacity.
Aging in skeletal muscle is characterized by loss of motor neurons, variations in size and type of muscle fibers, infiltration of fat and connective tissue, and a overall decrease in muscle mass (sarcopenia) [ 1].
In addition, the memristive devices are of the size of a motor neuron and the flexible/folded architectural form factor is critical to match brain cortex׳s folded pattern for ultra-compact design.
26, 27 Histological findings include loss of innervation of neuromuscular synapses, reduced muscle fiber size, and moderate motor neuron loss at 9 days.
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CMAP size is affected by pathological processes involving the motor neuron, axon, synapse, or the muscle.
The total number of motor neurons innervating trunk muscles actually decreases due to secondary motor neuron cell death [16], while the increase in neuromuscular synapse number and size persists.
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