Sentence examples for motor neuron models from inspiring English sources

Looking at our motor neuron models, we observed that GE reduced the paralysis and neuronal degeneration phenotypes caused by the expression of mutant mTDP-43 or mFUS and reduced the fraction of insoluble mutant proteins (Fig. 1D I), suggesting that GE may reduce the cellular load of toxic misfolded proteins.

It was observed in a study using motor neuron models, in cultures containing mutant SOD1G93A, through administration of adenovirus vector, that VEGF increased neurons survival [ 215].

Supplementary Figure 7 Integrate-and-fire motor neuron model.

"... To explore the relationship between conductances, and in particular how they influence the activity of motor neurons in the well characterized leech heartbeat system, we developed a new multi-compartmental Hodgkin-Huxley style leech heart motor neuron model.

Interestingly, in the motor neuron model, maturation is accompanied with an increase of XIAP and a decrease in its inhibitor XIAP-associated factor (XAF) levels.

These data represent an unprecedented therapeutic success in motor neuron disease models compared with other pharmacological/molecular treatments.

This conclusion is supported by the strategy taken by Gross and colleagues (2007) who used lentiviral vectors to reduce RHOA expression and promote regeneration of motor neuron in models of spinal cord ischaemia.

Motor neuron population model.

Transgenic mice over-expressing mutant human SOD1 have increased SOD1 activity and a loss of motor neurons that models human ALS, and mice carrying a mutant SOD1 transgene (tgSOD1G85R) on a normal mouse background compared with the same transgene in a SOD1 null background showed no change in survival.

Moreover, several studies have demonstrated that astrocyte-specific overexpression of Nrf2, an antioxidant transcription factor, reduces chemical-mediated neurotoxicity modeling PD and Huntington's disease, as well as genetically induced motor neuron degeneration in models of amyotrophic lateral sclerosis (ALS).

Re D B, Le Verche V, Yu C, et al. Necroptosis Drives Motor Neuron Death in Models of Both Sporadic and Familial ALS.