Sentence examples for motor neuron data from inspiring English sources
For brain tissues, miR-9 and miR-128b are Type I, although miR-128b is not found in the motor neuron data [38].
As expected, we found that the clr-1 transcript is enriched in the unc-4 GFP unc-4 GFPon data set.
Transcripts for genes with general roles in axon outgrowth are enriched in the unc-4 GFP unc-4 GFPon data set.
To test this idea, we evaluated GFP reporter lines for representative genes detected as enriched in the unc-4 GFP unc-4 GFPon data set (Fig. 5).
Therefore, we excluded all 729 of these wildtype-enriched transcripts from the list of present calls in the unc-4 GFP unc-4 GFPon data set (Additional file 6).
We will refer to microarray results from unc-4 GFP unc-4 GFPls as the " unc-4::GFP markedneuron" data set.
Although there were no observable abnormalities in soma of motor neurons (data not shown), we observed the degenerative and swollen axons with the accumulation of granular aggregates, disorganized fibrillar materials, multivesicular bodies (MVBs), and/or autophagosome-like vesicles in the spinal cord of Als2−/−;SOD1H46R and Als2+/+;SOD1H46R mice at an early symptomatic stage (Figure 3B and 3C).
Cytoplasmic mutant Seipin aggregates were present in very few cortical neurons, but in many spinal cord motor neurons (data not shown), indicating that mutant Seipin aggregates form early in life.
While the mutant AR shows primarily diffuse staining in the spinal motor neuron nuclei (data not shown), we were able to detect aggregates in the skeletal muscle of BAC fxAR121 mice via multiple assays.
The antibody concentration and treatment regiments were selected on the basis of in vitro motor neuron survival data shown in Figure 2. The dosing regimen provides trough antibody concentrations in serum of >200 μg/ml.
While this approach represents a unique way to prevent motor neuron loss, our data also suggest that additional strategies may also be required for maintenance of neuromuscular connections and full functional recovery.
