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The cerebellum is known to be the main structure for motor learning functions.
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Therefore, given these reports, we examined motor learning function in our own PTPN4 and PTPN3 single-deficient mice and in PTPN4/PTPN3 double-deficient mice.
Importantly, Purkinje cells are essential for controlling motor and learning functions, and motor symptoms were the first to be detected in this model (Fig. 1C).
Recently, we demonstrated that prenatal exposure to DEX in a primate, the common marmoset, had an impact on social development, skilled motor reaching/dexterity, motivational and learning functions [ 6].
We showed for the first time that exposure of the fetus to DEX has a long-term postnatal impact on social development, skilled motor reaching/dexterity, motivational and learning functions [ 6].
Higher brain areas control more cognitive and learning functions, while lower brain areas control more motor functions.
Behavioural tests were performed to analyse memory and learning functions (active avoidance and object recognition tests) and motor coordination (rotarod).
However, the cerebellum's role in motor learning [ 59] – but also in cognitive functions [ 60] – could be in reinforcement of the process rather than in the process itself.
Additionally, we show that two independent transgenic mouse mutants with impaired MLI function exhibit motor learning deficits.
Proprioceptive function can become enhanced during motor learning.
To further elucidate how the different interventions caused interference with motor learning all FT learning curves were fitted to a three-parameter power function y = y0+axb.
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