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Thus, the PTPN4-deficient mice reported here are on a mixed 129 SvEv×C57backgroundround whereas the PTPN4-deficient mice that were reported to exhibit motor learning defects are on a 129SvJ background [33].
Ifnb –/– mice had age-associated motor learning defects, neuromuscular deficiencies, and cognitive impairment.
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nf1-null larvae also demonstrate significant motor and learning defects.
Snord116 deletion mice have normal muscle strength but a defect in motor learning.
In Drosophila, the null phenotype manifests as a defect of axonal development, while knockout mice show impaired motor learning and cerebellar synaptic plasticity.
There is gross defect in recent memory and in learning (except perhaps in motor learning), with retrograde amnesia that initially may involve several years of the person's past.
Also, ATM−/− mice generated using gene targeting were characterized by motor learning deficiency, as well as ectopic and abnormal differentiation of Purkinje cells, although no obvious defects were found in their cerebella in one of the studies.
Motor learning principles for neurorehabilitation.
These characteristics have been attributed to a possible defect in the pre- and postnatal development of specific neural networks including the dentate-thalamo-cortical pathway, which is involved in motor learning, automaticity of movements, and higher cognitive functions.
Furthermore, abnormalities in basic motor control, skilled motor gestures, and motor learning, are common in ASD.
Ito, M. Mechanisms of motor learning in the cerebellum.
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