The VS has been described as a 'limbic motor interface' (Mogenson et al., 1980) linking motivation to the selection (Nicola, 2006; Humphries & Prescott, 2010) and invigoration (McGinty et al., 2013) of behavioural responses.
The CT domain contributes the side chains of Glu711 and Glu712, forming charged 'fingers' that dip into the cavity lining the dimeric motor interface to further stabilize the interface.
Use of EG with gross motor interfaces has become one of the standard treatments in rehabilitation therapies to increase fitness, and sedentary games increase health-related knowledge and encourage pro-health behaviors [ 10].
EG which have gross motor interfaces, such as the Dance Dance Revolution Dance Mat, WiiMote, and Xbox Kinect, provide physical challenge and a greater variety of physical operations when compared to games with conventional controllers.
The basal ganglia mediate this process by forming an emotion-motor interface where reactions to motivating stimuli could guide actions.
Integration of reward perception and motor information in the NAcc has given rise to the idea that NAcc serves as limbic-motor interface [26].
This "dorsal stream" of speech perception from auditory regions to inferior frontal regions may provide a sensory-motor interface that is important for mapping perceived speech onto articulatory processes [34], [35].
This recalls the notion of a limbic-motor interface (see Heimer 2003) but set here in the mesopontine tegmentum rather than forebrain.
Alternatively, the ventral striatum is associated with motivational aspects of emotionally significant stimuli (Cardinal, Parkinson, Hall, & Everitt, 2002) and is thought to represent a 'limbic-motor interface' where motivationally significant information can guide behaviour (Mogenson, Jones, & Yim, 1980).
First, we need an explanation for why left vSMG acts simultaneously as a phonological buffer/sensory-motor interface for speech (Baddeley 2003; Hickok and Poeppel 2007; Rauschecker and Scott 2009), and bilaterally, it supports bottom-up attention (Corbetta et al. 2008).
This system provides the basis for interactions between stimulus reward associative processing in the amygdala and the primary site mediating the reinforcing effects of addictive drugs, the ventral striatum, thereby underlying both pavlovian and instrumental appetitive behaviours – much as Mogenson et al. (1984) had predicted when describing this system as a 'limbic-motor interface' (Fig. 2).
