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Adolescent C57BL/6J mice were treated with bPiDI 30 min prior to testing the mice for binge-like ethanol consumption in the drinking-in-the-dark (DID) test, ethanol-induced motor incoordination using the balance beam, and ethanol-induced sedation using the Loss of Righting Reflex (LORR) paradigm.
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Degree of motor incoordination was evaluated using inclined beam-walking test and lateral push test.
Rotarod method was used to evaluate motor incoordination by determining the mean fall-off time.
None of drug doses used in this study caused sedation or motor incoordination in naïve rats.
SSRI antidepressants A serotoninergic syndrome can occur in the case of contemporary use of triptans and consists in motor incoordination, marked asthenia and hyperreflexia.
Although dosing in humans generally is less than 0.1 mg/kg, none of the drug concentrations used for the animals in this study caused sedation or motor incoordination.
Motor incoordination and impairment of speech and sight subsequently develop.
Rota-rod test was employed to assess motor incoordination.
The highest PPV was found with the "blank and vacant look" (100%), and "motor incoordination" (81%) signs [25].
I-R resulted in marked cognitive impairments, motor incoordination in mice, significant brain damage and increased oxidative stress.
The treatments were compared regarding the affect on analgesia, sedation, motor incoordination, salivation, heart rate, respiratory rate, rectal temperature, arterial pressure, central venous pressure and the electrocardiogram.
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