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Besides glial cell activation, motor neuron loss is considered as another major characteristic of spinal cord injury which contributes to motor functional deficits, especially at the cervical level.
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Patients often have neurological deficits such as sensory and motor, cognitive, functional deficits (hemiparesis, dysphasia, ataxia) and psychosocial (personality changes, loss of insight or empathy) factors due to tumour localisation or remote effects.
Conclusion: There is a strong association between motor function deficits and hypopharyngeal sensory deficits.
These animals also demonstrated motor function deficits.
Intracerebral grafting of BDNF-transduced hATSCs significantly improved motor recovery of functional deficits in MCAo rats.
This seems appropriate considering that muscle weakness, sensory changes, altered motor control and functional deficits are characteristic of this chronic condition.
Stroke is one of the main causes of long-term motor disability worldwide and in more than 85% result in functional deficits in motor control. 1 Currently, about 75% of patients affected by a stroke survive 1 year or more and this proportion will increase in the coming years due to improving quality of care.
In summary, our findings demonstrate that both loss and gain of TDP-43 function result in functional deficits whereby impaired synaptic transmission and defective motor behavior precede progressive deconstruction of neuronal connections, ultimately causing age-related neurodegeneration.
Impairments in motor performance may relate to functional deficits.
SCI interrupts descending motor tracts and causes persistent functional deficits due to the absence of spontaneous axon regeneration and the formation of large cavities.
Injuries to the anterior cruciate ligament (ACL) are the most frequent knee injuries in sports and cause immediate disability for athletes followed by long-term consequences in terms of functional deficits in motor coordination [3, 17, 25, 55].
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