The finding that a rapid development of motor deficits was associated with a worse functional outcome could be explained by the fact that a rapid decline in motor function was caused by disruption of the arterial blood flow resulting in spinal cord infarction [ 7, 8].
Indeed, the disruption of motor function is a major source of impairment affecting both upper and lower limbs, frequently impeding autonomy in the activities of daily living (ADL) [ 4, 5].
Some, but not all, of these models show disruptions of gross motor function.
In patients with poor motor cortex excitability to TMS, motor function dropped off rapidly with increasing corticospinal disruption (Stinear et al. 2007).
Motor function is regulated by dopaminergic corticostriatal circuitry, and extensive evidence points to disruption of these networks in ADHD (see: del Campo et al., 2011).
Taken together with past research, our findings indicate that gross motor function in adult ASD mouse models is not a necessary consequence of disruption in cerebellum-dependent learning.
A similar observation has been made using a diffusion tensor imaging measure of corticospinal tract disruption, in a homogeneous group, and relating this measure to motor function (Stinear et al. 2007).
These disruptions, together with developing deficits in metabolism [32] and motor function [35], might have left the R6/2 mice increasingly more tired and less rousable than their WT littermates.
Still, he had made vast improvement in motor function.
Doctors said Hodari had full motor function and was progressing.
