Depending on the severity of the condition, babies born with microcephaly often develop with cognitive problems or other developmental issues including impaired motor functions, coordination, and speech.
It is clear that the cerebellum contributes to motor functions, coordination, and balance.
The cerebellum's contribution to motor functions, coordination and balance [ 5- 8], and to associative and non-associative motor learning [ 9- 15] is clear.
These motor impairments may model those seen in XYY humans, such as impairments in gross motor function and coordination [ 37, 38].
By immunohistochemistry, CA XIV showed a unique distribution in neurons of mammalian brain, and was expressed particularly strongly in neurons involved in motor function and coordination [ 7].
For determining motor function and coordination, a rotarod testing was done in R6/2 HD mice and their WT by using a standard rotarod (Ugo Basile North America Inc., Schwenksville, Pennsylvania, USA).
Motor function and coordination were unchanged as measured by time spent on the rod (for four trials a day for four days) in rotarod (E ) and footslips per centimeter traveled in parallel rod footslip (F ).
In other words, patients treated with the Additional Protocol developed a greater recovery of motor function and coordination than patients treated only with the conventional protocol, both at the end of therapy and at follow-up (8 months).
The cerebellum has a well-established role in controlling motor functions such coordination, balance, posture, and skilled learning.
