Sentence examples for motor dysfunction showed from inspiring English sources

Three month-old Tg+ mice, prior to developing clinical signs of weakness or motor dysfunction, showed no significant difference in VWR compared to Tg− littermates, as determined by distance, time, and speed on the wheel (Fig. 7D).

The spinal cords of young and middle-aged JNPL3 mice that lacked motor dysfunction (Fig.  2a, b) showed normal nuclear localization of pTDP-43; however, the spinal cords of JNPL3 mice that had motor dysfunction showed striking cytoplasmic redistribution of pTDP-43 (Fig.  2c).

The study, conducted on a group of 15 healthy volunteers and 15 patients with masticatory motor system dysfunctions, showed high accuracy and repeatability of measurements made using two pressure algometers, with the intraclass correlation coefficient within a range between 0.73 and 0.99.

Motor dysfunction has been shown to precede neuropathology in BACHD mice.

Clinically, C9ORF72 expansion cases with motor neuron dysfunction show features of classical ALS with a relatively rapidly progression.

To investigate whether treated mice showed motor dysfunction, we performed an accelerating rotarod test, which provides a more discriminating way to correlate motor deficits against lesion size [37].

Mice expressing the homologue of the human D178N (129V) mutation showed motor dysfunction, alteration of spatial working memory and abnormal EEG pattern and sleep disturbances [ 36], histologically punctate, micro-plaque like deposits, and ultrastructurally a swelling of the endoplasmic reticulum of cerebellar granule neurons.

For further details see Table 3 and Figure 3. *p < 0.05 Bland and Altman plots are shown for Motor Dysfunction and Seizures to exemplify extent of rater agreement across the scale range.

In contrast, hemizygous animals have no gross pathological changes in either the brain or spinal cord at 12 weeks and show no evidence of motor dysfunction out to 104 weeks.

In addition, GI SMCs from patients with ulcerative colitis, an idiopathic inflammatory disease of the colon, showed an abnormal motor dysfunction in the colonic circular muscle while the muscularis propria contained increased pro-inflammatory cytokine signals [59].

Als2−/−;SOD1H46R mice showed an earlier motor dysfunction, in which the onset of disease (∼15 weeks of age) was approximately 3 weeks earlier than those (∼18 weeks of age) of Als2+/+;Sor1H46R or Als2+/−;SOD1H46R littermates (Figure 2A).