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Rather, it is possible that the extremely rapid progression of motor dysfunction observed in high-copy number SOD1G93A mice could overwhelm the modest symptoms by the ALS2 deficiency [29].
The motor dysfunction observed in neural-specific Nf1hGFAPCKO mice suggests possible defects in the cerebellum.
Primary motor cortical (M1) adaptation in the form of altered organisation and function is hypothesised to underpin motor dysfunction observed in chronic pain.
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No complication occurred during surgery, and no cognitive and motor dysfunctions were observed 1 h after surgery.
While causality cannot be determined in this study, we have not observed motor dysfunction without CNS vascular permeability in the PIFS model.
Indeed, postmortem brain samples of HD patients exhibit reduced activity of mitochondrial respiratory complexes II, III and IV (Ref. 84); and humans exposed to 3-nitropropionic acid (3-NP), a selective inhibitor of succinate dehydrogenase and complex II, exhibit motor dysfunction similar to that observed in HD patients (Ref. 85).
No overt motor dysfunction or behavioral impairment was observed.
Accordingly, our observations provide a potential link between abnormal 'entero-gastric' responses [ 17] and the frequently observed gastric motor dysfunction and delayed emptying in the critically ill [ 16- 18, 21].
Sedation and motor dysfunction were assessed by visually observing motor activity following injections.
The reason for conducting Experiment 1b was to exclude motor dysfunction as cause for group differences observed in 1a.
As the PC is also involved in motor tasks, Experiment 1b (number naming) was conducted to exclude motor dysfunction as cause for deviations potentially observed in 1a.
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