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Objectives This study aimed to compare the sedative and analgesic effects and the recovery profiles of propofol and midazolam in a rat model by conducting motor coordination tests (rotarod-accelerod test) and by evaluating the analgesic response times by conducting hot plate and tail flick tests.
In motor coordination tests, the performance of Delphilin mutant mice was also comparable to that of wild-type mice under the conditions used.
Each cohort of mice was tested on a battery of motor coordination tests at 3, 6 and 12 months of age, including rotarod testing, the pole test, and nest construction.
Behavioral results in the water maze test were in line with the aforementioned motor coordination tests.
We did not observe any rescue in the novel object recognition or the rotarod (motor coordination) tests.
In AD behavioural studies, in particular among the motor coordination tests, the rotarod performance has been reported to be impaired in some AD transgenic mice models bearing A β plaques [ 50, 51].
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Desrosiers J, Rochette A, Corriveau H. Validation of a new lower-extremity motor coordination test.
For comparison between class1 or class2 scFv effect on mice balance for motor coordination test the Wilcoxon test was used.
Weight and forelimb muscle strength did not differ as well as motor coordination tested by two different tasks.
Another motor coordination test was included that evaluated average running performance on an accelerating rotarod.
The anxiolytic activity was examined by using the light/dark box test and the hole board test, and motor coordination test assessed with the rota rod test.
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