In order to preserve physical functioning, and thus quality of life, it is of particular importance to understand the extent to which muscle strength, motor coordination, and flexibility contribute to functional performance.
Exactly how the cerebellum contributes to motor coordination, however, remains controversial.
It is possible that an accelerated maturation of circuits regulating motor coordination, due to enrichment, is contributing to the differences in performance observed in enriched neonates.
The current findings indicate that motor coordination, sensory integration, and disinhibition contribute to the latent construct of neurological soft signs, whereas the subset of neurocognitive function tests contribute to the latent constructs of executive attention, verbal memory, and visual memory in the present sample.
On the other hand, the Motor Coordination, Sensory Integration, and Disinhibition contributed to "Neurological Soft Signs".
Interestingly, a recent study from our group [ 24], adopting structural equation modeling, showed that motor coordination, sensory integration, and disinhibition contributed to the latent construct of neurological soft signs, whereas the subset of neurocognitive function tests contributed to the latent constructs of executive attention, verbal memory, and visual memory.
For the structural model, it shows the relationships between the conventional neurocognitive functions, i.e., Executive Functions, Verbal Memory, and Visual Memory, and the latent variable of Neurological Soft Signs (which was contributed by the motor coordination, sensory integration, and disinhibition).
The current findings indicate that, on the one hand, in the measurement model of the SEM that motor coordination, sensory integration, and disinhibition subscales contributed to the latent construct of neurological soft signs, whereas the subset of neurocognitive function tests contributed to the latent constructs of executive attention, verbal memory, and visual memory in the present sample.
Taken together, these diverse findings suggest that As-induced changes in these brain regions may contribute to deficits in motor coordination.
The impaired functioning of inhibitory GABAergic neurons may contribute to seizures, ataxia, spasticity and failure of motor coordination observed in these mice.
