Specifically, elucidating the sensory experience, internal integration, and motor consequences of joy, sorrow, rage, and despair is critical for knowing what it means to be alive, conscious, and self-aware.
Motor problems in ADHD have been seen as being co-effects or a motor consequence of inattention and impulsivity [ 12].
Such behaviour may be considered a motor consequence of an intolerance to uncertainty, namely, an index of motor impulsivity [ 42, 45].
Thus the decreased freezing to ambiguous cues is unlikely to be due to some general sensory or motor consequence of 5-HTT over-expression.
Patients should be made aware of these common complications and the likely clinical effects, including sensory and possible motor consequences.
Under our hypothesis, we would expect a higher sensory area such as the precuneus to be the site of strong prediction errors stemming from a mismatch between the actual and intended (i.e. predicted by pre-supplementary motor area but not by lower motor levels) sensory consequences of movement, hence its activation as a main effect of paralysis is unsurprising.
The idea that the motor cortex specifies consequences of, rather than instructions for, movements is not a new one.
By capturing the new relationship between motor commands and their desired sensory outcomes, predictions related to the consequences of motor commands (forward model), and the motor commands required to achieve a desired output (inverse model) can be made [5], [6], [7], [8].
We propose a possible solution to this problem, termed decorrelation control, in which the cerebellum learns to decorrelate the motor command sent to the muscles from the sensory consequences of motor error.
Returning to the example of Stetson et al.'s [1] visuo-motor effects, a single, late-stage timing mechanism might be expected to recalibrate all the self generated sensory consequences of motor actions in a similar manner [16].
The sensory consequences of motor error were retinal slip, delivered as climbing fiber input to the flocculus.
