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Motor behavioral tests were performed the fourth week after transplantation.
Animals were subjected to motor behavioral tests at 4 week posttransplant survival time.
A battery of motor behavioral tests was conducted on day 8 and 15.
Functional efficacy was assessed with drug-induced and spontaneous motor behavioral tests where vector-treated animals showed near complete and stable recovery within 1 month.
Baseline motor behavioral tests were performed by a blinded tester 1 3 days prior to surgery, and then post-operatively 1 x/wk until end-stage, which was defined as the day at which they were unable to right themselves within 30 sec of being placed on either side [55].
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Conventionally, this is done by monitoring motor functions with behavioral tests or by invasive methods, such as in vivo microdialysis.
It is known that even the general population of DAT-KO mice displays minor motor impairments in several behavioral tests.
Crawley, J. N. Behavioral phenotyping of transgenic and knockout mice: experimental design and evaluation of general health, sensory functions, motor abilities, and specific behavioral tests.
Behavioral phenotyping of transgenic and knockout mice: experimental design and evaluation of general health, sensory functions, motor abilities, and specific behavioral tests.
Animals receiving atipamezole plus rehabilitation exhibited significantly greater motor improvement in both behavioral tests as compared to vehicle-treated animals receiving rehabilitation.
The behavioral tests for motor and sensory function were performed before and after injury, and weekly after transplantation, with some animals also tested for bladder function at the end of the experiment.
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