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The physiological fluidity of each discretely-arrayed bilayer is truly what enables the study of membrane processes, which often require the dynamic lateral motion of proteins and lipids.
To my knowledge, this is one the first, if not the first, study to track intra-nuclear motion of proteins at such high space and time resolution.
The ability and mode of motion of proteins and RNAs has implications for how they find nuclear targets on chromatin and in nuclear subcompartments and how macromolecular complexes are assembled in vivo.
Somewhat counter-intuitively, the non-directional, but rapid, motion of proteins within the cell nucleus provides a means to ensure targeting of proteins to specific genome locations (Misteli 2001).
In other words it is a direct consequence of the thermal behavior of internal motion of proteins in solution and has nothing really to do with a global concerted glass transition driven by the freezing of solvent.
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KSI binds substrates at a surface cleft, TIM binds substrate at an exposed 'cage' formed by closure of flexible loops; and, DAP epimerase binds substrate in a tight cage formed by an 'oyster-like' clamping motion of protein domains.
For two kinds of biomolecules, when the temperature is low, increasing temperature could lead to increasing thermal motion of protein molecules, which can promote protein migration; when the temperature continues to rise, when the molecular collision greatly increases, translocation current will decrease.
Elastic network models have been well-accepted for studying the large-scale motion of protein structures in recent years (Chennubhotla et al. 2005; Nicolay and Sanejouand 2006; Bahar et al. 2010; Gniewek et al. 2012).
Recent project: supercomputer that Shaw designed allows scientists to run detailed simulations exploring the motions of proteins.
A battery of NMR experiments is now available to probe the motions of proteins and nucleic acids over the whole biologically relevant timescale from picoseconds to hours.
The intrinsic motions of proteins, determined by covalent and non-covalent forces, cause conformational changes with intermolecular and intercellular ramifications on signaling pathways, cell function, and physiological responses.
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