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Initially, the data underwent rigid body realignment to correct for head movement using rigid body motion correction procedure (Friston et al. 1996).
In our method, to accurately estimate the motion vectors of the background pixels located in the central part of the blocks, we start the motion correction procedure with those background pixels that have higher number of neighbouring pixels with correct motion-values.
Although there is no bulk motion correction procedure used for the IF-IBDV method, the vessels are clearly visible in the IF-IBDV image.
Briefly, for each subject, we removed sources of variance of noninterest including all motion parameters measured during the motion correction procedure, the mean whole-brain signal, the mean signal from the lateral ventricles, and the mean signal from a region within the deep cerebral white matter.
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Motion artifacts may remain after standard motion correction procedures for large scan-to-scan movements (Diedrichsen & Shadmehr, 2005).
The six rigid-body motion parameters from the motion correction process were also regressed out from the time series.
However, for the present study, this did not cause any problems during the motion correction process.
After the realignment procedure for motion correction among the frames, motion corrected PET frames were summed, co-registered to the corresponding individual MRI and transformed into standardized stereotaxic space.
Motion correction regressors (from the realignment procedure) were entered as covariates of no interest.
After the procedure of head motion correction, the values for translation (mm) and rotation (degrees) were obtained at each time point in six parameters (three for translation and three for rotation) for each participant.
A total of 14 regressors for physiological noise reduction and 6 motion correction regressors estimated from the realignment procedure were entered as covariates of no interest (physiological data were available for all but 2 participants, for whom just 6 motion correction regressors were entered).
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