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To explore this possibility, we compared motion coherence thresholds of children with amblyopia (7 14 years old) to age-matched controls.
Computer-based assessments included measures of visual sensitivity (central and peripheral motion coherence thresholds), transient spatial attention (a useful field of view - dual task paradigm), and sustained attention (multiple-object tracking).
However, it should be noted that there is debate in the global motion literature with some studies finding no difference between Control and ASC groups [32] and others finding that only a subgroup of the ASC participants have motion coherence thresholds outside the normal range [31], [33] [35].
Migraine groups have elevated motion coherence thresholds [7], [8], [23] for random-dot-motion stimuli that require global integrative mechanisms such as those present in V5 [59] Structural increases in cortical thickness in areas V5 and V3a have been reported in individuals with migraine as well as subtle white-matter changes in the superior colliculus revealed with diffusion tensor imaging [60].
Although levels of internal noise reduced with age, these did not predict motion coherence thresholds.
Finally, we investigated the relationship between fixation stability and motion coherence thresholds.
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Next, the internal noise, sampling and motion coherence threshold estimates in each speed condition were assessed for skewness and kurtosis.
Each series was repeated three times and the mean of two best series comprised individual's overall motion coherence threshold (Talcott et al. 2000).
In contrast, the motion coherence threshold for the patients with right ventral visual lesions was significantly impaired, with thresholds three to four times higher than those of the matched controls (see Table 2, Fig. 1A and Supplementary material for further supporting results and analyses).
As detailed in Table 3 and displayed in Fig. 1A, and consistent with the motion coherence threshold results, EL, the left ventral patient, performed normally in all conditions, while the performance of SM, the right ventral patient, was out of the normal range for the slower (5.4°/s) and the fastest (27.27°/s) speeds, but not the medium speed (10.8°/s).
It is important to emphasize that we kept the experimental paradigm as close as possible to that of the motion coherence threshold paradigm, including the timing and duration of the trials, the size, colours and luminance of the circular display, the number, size and colour of dots in the display, and the lifetime of the dots (for the dots in the signal and the noise dots).
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